08 July 2009,
From 'Ask Ausiello':

Question: What the heck has the awesome Melinda Clarke been up to? --Tammy
Ausiello: Big scoop: She's starring in a new TV series as a housewife by day and a spy by night. Unfortunately, the show isn't real; it's part of an upcoming Entourage subplot.

P.S. I've heard that Autumn Reeser (Taylor) is also starring in the new season of Entourage, I will post more detail's about that soon!